John Frusciante’s genius is that while he’s not a “perfect technique” guitarist, he can come up with licks that are both melodically superb, easy to play, and full of rhythm and feel. Can’t Stop’s riff is just that. It’s a bass pattern with a repeating lick, and once you get the correct fingering down, it’s fun to play and you can loop it as long as you want, as well as improvise on its rhythm and ideas.
A note on the picking: To get the right sound for this riff, you need to play it with alternate picking, meaning no matter which string you’re playing, or where you’re going string-wise, you need to keep picking up-down-up-down all the time. We’ll discuss alternate picking in a different video.